Table 4 Variables assessed at specific times (S: screening, M: month)

Primary outcome

Global cognition

ADAS-Cog

x

x

x

x

x

Secondary outcome

Brain volumes

Hippocampal volume

MRI

x

x

x

Brain volume

MRI

x

x

x

Ventricle volume

MRI

x

x

x

Other outcomes

Discreet cognitive domains

Attention

Digit Span (Wechsler)

x

x

x

x

x

Processing speed

Digit Symbol (Wechsler)

x

x

x

x

x

TMT Part A

Executive function

TMT Part B

x

x

x

x

x

EXIT-25

BDS Executive Clock Drawing test

Memory

Logical Memory Story A and B

x

x

x

x

x

Immediate Recall

Delayed Recall

Language

Verbal Fluency

x

x

x

x

x

Animal

Vegetable

Naming

Boston Naming Test

Exercise adherence

Percent

Every exercise session

Aerobic fitness

Symptom-limited peak cycle-ergometer test,

x

x

x

x

x

Shuttle-walk test, 6-minute walk test

x

x

x

x

x

Physical function

SPPB, DAD

x

x

x

x

x

BPSD

NPI-Q, AMS, CSDD

x

x

x

x

x

Medical changes

Medical diagnoses, falls, medications, and health care service use

Monthly

Covariates

AD stage

CDR, MMSE

x

Demographics

Age, education, gender, race

x

Premorbid intellect

WTAR

x

Unsupervised physical activity

PASE, actigraph

Monthly