Prevention of post-mastectomy neuropathic pain with memantine: study protocol for a randomized controlled trial

Table 1 Summary of evaluation for a patient

Visit	Screening/informed consent	Surgery (mastectomy)	Hospital stay	Follow-up	Follow-up	Follow-up
Day of visit	D_0-15	D₀	D₀ to D_0 + 15	D_0 + 15	D_0 + 3 months	D_0 + 6 months
Filling of questionnaires
1- Pain
Numerical Scale	+	-	+	+	+	+
DN4	+	-	-	+	+	+
NPSI	-	-	-	+	+	+
BPI	-	-	-	-	+	+
McGill pain questionnaire	-	-	-	-	+	+
2- Cognition
Trail Making Test	+	-	-	+	+	+
Digit Symbol Substitution Test	+	-	-	+	+	+
3- Quality of life
SF-36	+	-	-	+	+	+
4- Sleep
Leeds questionnaire	+	-	-	+	+	+
5- Anxiety/Depression
HAD scale	+	-	-	-	+	+
6- Concomitant medication recording
Treatments (analgesics, antidepressants, etc.)	+	+	+	+	+	+

+, Questionnaire performed; -, questionnaire not carried out; BPI, Brief Pain Inventory; DN4, Neuropathic Pain in 4 questions; HAD scale, Hospital Anxiety and Depression Scale; NPSI, Neuropathic Pain Symptom Inventory; SF-36, Short-Form-36.

ISSN: 1745-6215