Table 5 Example of sample size calculation for the joint test under PH

From: An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

Power of test under PH		Target HR	Sample size
Logrank	Joint		n	events
0.8	0.709	0.70	378	248
		0.75	570	380
		0.80	931	632
0.9	0.835	0.70	506	332
		0.75	763	509
		0.80	1246	845
0.874	0.8	0.70	464	304
		0.75	700	467
		0.80	1142	775
0.945	0.9	0.70	610	399
		0.75	919	613
		0.80	1500	1018

The power for the logrank test is given in the first column. The corresponding power of the joint test is shown in the second column.

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ISSN: 1745-6215

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