Reference | Type of study | Study population | Study intervention | Study outcome |
---|---|---|---|---|
[14] | Non-randomized trial | Surgical ICU patients | Salt-poor albumin (n = 8) versus furosemide alone (n = 5); all patients received furosemide | Improved oxygenation as measured by ADO2 at 2 hours |
[17] | Retrospective observational study | Medical ICU patients (n = 31) | Case patients received 25% albumin; control patients did not; all patients received furosemide infusion | No change in urine output or fluid balance |
[18] | Randomized controlled trial | Mechanically ventilated patients with congestive heart failure ( n = 30) | 250 mg frusemide diluted in 12.5 g albumin at a rate of 0.1 mg frusemide/kg/hour versus furosemide infusion alone | No difference in urine output or fluid balance at 24 hours |
[15] | Retrospective observational study | ICU patients | Cases patients (n = 30) received at least four doses of 100 ml 25% albumin; control patients (n = 25) received no albumin | No change in oxygenation, hemodynamics; higher positive fluid balance in cases |
[19] | Randomized controlled trial | Mechanically ventilated patients with ARDS ( n = 40) | 100 ml of 25% albumin every 8 hours versus placebo; furosemide infusion | Improved oxygenation, greater net negative fluid balance, better maintenance of hemodynamic stability |
[16] | Prospective matched case-control study | Mechanically ventilated patients with acute lung injury or ARDS | Case patients (n = 57) received 200 ml of 20% albumin and Lasix infusion; control patients (n = 57) received usual care | Lower net fluid balance, shorter ICU stay, reduced duration of mechanical ventilation; lower mortality |