Developmentally adapted cognitive processing therapy for adolescents and young adults with PTSD symptoms after physical and sexual abuse: study protocol for a randomized controlled trial
© Rosner et al.; licensee BioMed Central Ltd. 2014
Received: 7 February 2014
Accepted: 6 May 2014
Published: 29 May 2014
Although childhood sexual and/or physical abuse (CSA/CPA) is known to have severe psychopathological consequences, there is little evidence on psychotherapeutic interventions for adolescents and young adults suffering from post-traumatic stress disorder (PTSD). Equally sparse are data on moderators of treatment response on PTSD-related epigenetic changes, health care costs and loss of productivity, alterations in cognitive processing, and on how successful interventions affect all of these factors. Early treatment may prevent later (co)morbidity. In this paper, we present a study protocol for the evaluation of a newly developed psychotherapeutic manual for PTSD after CSA/CPA in adolescents and young adults – the Developmentally Adapted Cognitive Processing Therapy (D-CPT).
In a multicenter randomized controlled trial (RCT) D-CPT is compared to treatment as usual (TAU). A sample of 90 adolescent outpatients aged 14 to 21 years will be randomized to one of these conditions. Four assessments will be carried out at baseline, at end of treatment, and 3 and 6 months after end of therapy. Each time, patients will be assessed via clinical interviews and a wide range of questionnaires. In addition to PTSD symptoms and comorbidities, we will evaluate moderators of treatment response, epigenetic profiles, direct and indirect costs of this disorder, and neurophysiological processing of threat cues in PTSD and their respective changes in the course of these two treatments (D-CPT and TAU).
The study will provide new insights in the understudied field of PTSD in adolescents and young adults. A newly developed intervention will be evaluated in this therapeutically underserved population. Results will provide data on treatment efficacy, direct and indirect treatment costs, as well as on associations of treatment outcome and PTSD intensity both to epigenetic profiles and to the neurobiological processing of threat cues. Besides, they will help to learn more about the psychopathology and possible new objective correlates of PTSD.
Germanctr.de identifier: DRKS00004787.
KeywordsAbuse Adolescents Cognitive processing therapy Post-traumatic stress disorder
Unfortunately, traumatic experiences in childhood and adolescence are common: a meta-analysis based on 65 international studies indicates that nearly 20% of women and 8% of men experienced sexual abuse prior to the age of 18 . Regarding physical abuse in Western and European nations, numbers range from 3.6% to 16.3% [2–5]. These negative childhood experiences do not only have short-term consequences concerning the victims’ mental health – they are also related to a number of psychiatric disorders during the whole life span . Consequently, people exposed to childhood sexual abuse (CSA) have a 2.4 heightened risk for the development of psychopathology compared to those without such experiences. For childhood physical abuse (CPA), this factor is around 1.5 . In a meta-analysis, mortality and morbidity, drug and alcohol misuse, risky sexual behavior, obesity, and criminal behavior were found as consequences of childhood maltreatment . According to Cutajar et al. , CSA increases the risk for several mental diseases like psychosis, affective, anxiety, substance abuse, and personality disorders. There is a particularly high probability for the development of post-traumatic stress disorders (PTSD) – exposure to CSA leads to an increased PTSD risk of 5.6 compared to non-CSA exposure. Accordingly, international studies show a high prevalence for PTSD after CSA, which ranges from 37% to 44% [10, 11]. However, victims of CSA do not only suffer from PTSD; comorbidity secondary to PTSD often develops during adolescence and early adulthood, moderated by the patient’s efforts to fight painful trauma-related emotions, for instance by using harmful substances and by developing suicidal, self-injurious, or other severely dysfunctional behavior [12, 13]. Early pregnancies and re-victimization occur at higher odds than in the general population [14, 15].
Given these negative consequences, it is obvious that abuse-related PTSD should be treated at an early stage. For children, there already exist evaluated interventions: a meta-analysis of 39 studies analyzing treatment results for children and adolescents with psychiatric symptoms after CSA reported a general effect size of g = 0.77 for PTSD symptoms in the 5 studies with controlled designs and an untreated comparison control group. For the other studies, the authors report pre-post effect sizes of g = 1.13 for PTSD . In contrast, few randomized controlled trials (RCTs) for PTSD therapy of adolescents were included in this meta-analysis – only two studies enrolling adolescents over 14 years of age used control conditions (waiting list/supportive treatment) and randomization [17, 18]. However, as the mean age in both studies was around 11 years, the majority of participants were children. To our knowledge, there exist only five studies examining treatment effects on post-traumatic stress symptoms after CPA or CSA among adolescent patients exclusively [19–23]. Being the first of their kind, these studies are undoubtedly important. However, most of them have methodological deficits like caseness not defined by PTSD diagnoses or the use of insufficient diagnostic instruments. Only the study of Foa et al.  meets the standards for controlled studies, although it only focusses on girls. In summary, adolescents beyond the age of 14 are inadequately represented in PTSD research so far.
Thus, the major goal of the presented project herein is to provide information on treatment efficacy in this understudied group. A highly effective cognitive behavioral therapy manual for adults, Cognitive Processing Therapy (CPT ), was adapted for adolescent patients with CSA/CPA-related PTSD  – the Developmentally Adapted Cognitive Processing Therapy (D-CPT). Four major adjustments were integrated in the protocol. First of all, the treatment intensity was increased by administering the middle part of the protocol in high frequency (approximately 15 sessions during four weeks) to enhance the adolescents’ motivation; applying treatment in such intensity was reported to be superior to the usual scheme of one session per week . Second, a commitment phase was included in the protocol in order to further build treatment motivation and to enhance therapeutic alliance as well as to establish the formal framework that is needed to conduct therapy. As survivors of childhood abuse often experience difficulties in emotion regulation, behavior and emotion management techniques, as used within Dialectical Behavior Therapy for PTSD (DBT-PTSD [27, 28]), were also integrated in D-CPT. Finally, special consideration was given to developmental tasks affecting the patient’s entire life, such as career choice, vocational training, and romantic relationships. Adolescent patients are at high risk of school or secondary education drop out, of starting relationships with abusive partners, or of becoming re-victimized. Therefore, we decided to specifically address these issues at the end of treatment.
D-CPT has already been successfully piloted; nearly all of the 12 participating patients showed large reductions of post-traumatic stress symptoms and, moreover, comorbid symptoms improved significantly as well . In October 2012, our research group started its work on the RCT and the associated studies. This article introduces its study protocol.
The current trial
The overall aim of this RCT is to demonstrate the efficacy of a newly adapted psychotherapy intervention protocol in comparison to treatment as usual (TAU) in the understudied population of physically and sexually abused adolescents and young adults suffering from PTSD. Severity of PTSD symptoms before and after therapy serves as a primary outcome. Secondary goals are to evaluate changes in general psychopathology and comorbidity, such as depression, borderline personality features, and dissociation. Thirdly, the trial will allow for an estimation of the efficacy of TAU in Germany, on which currently no data is available.
Adjunct projects will provide new insights in questions beyond treatment efficacy; electroencephalographic (EEG) parameters are collected in an experiment which aims to find neuronal correlates of threat processing evoked by different categories of emotional words. Preliminary studies could show that anxiety disorders modify the way threatening information is processed . By adapting these studies to the current project, multiple research questions may be answered. Namely, it will be possible to investigate differences in information processing between healthy subjects (control group), traumatized but healthy subjects (trauma control group), and traumatized subjects with PTSD (experimental group). In addition to this, the influence of D-CPT on information processing can be assessed on a psychophysiological level.
On the basis of questionnaires and videotaped sessions, potential predictors of treatment success are analyzed. As there is little research about handling PTSD in adolescents, also important variables influencing therapy outcome, such as treatment adherence, therapist competence, and working alliance, are not well studied . Equally sparse is data about societal costs for the treatment of PTSD and/or mental comorbidities like depression or anxiety disorders (direct costs) as well as PTSD-related loss of productivity (indirect costs). No study has ever investigated the indirect costs resulting from PTSD in adolescents and, so far, no study has analyzed any cost data of PTSD or PTSD-treatment in Germany. Using different questionnaires, these issues are addressed in the D-CPT-project.
Concerning the genetic basis of PTSD and therapy outcome, there are only very few (though promising) clinical studies indicating epigenetic changes in PTSD in humans (for example ). In our study, the analysis of epigenetic profiles of PTSD patients by saliva samples during the course of therapy is realized via high-throughput epigenetic profiling.
D-CPT is an open, rater-blinded, multicenter, 2-arms RCT comparing D-CPT to TAU in Germany. There are five assessments: at baseline, within the treatment (approx. 8 weeks after beginning), directly after end of treatment (post-treatment) as well as 3 and 6 months after end of treatment (follow-up 1 and 2).
Adolescents and young adults aged 14 to 21 years may take part in the study. For inclusion, PTSD as a primary diagnosis after experiencing CSA and/or CPA beyond the age of three, according to the definition of the American Psychological Association , is required. To be diagnosed with PTSD, patients must meet 1 B-criterion, 2 C-criteria, and 2 D-criteria in the Clinician Administered PTSD Scale for Children and Adolescents (CAPS-CA ). A stable psychopharmacological medication is necessary at study entry, i.e., in the last 3 weeks there was either no or a constant psychopharmacological medication. Moreover, living in safe conditions, a sufficient knowledge of German language, as well as an informed consent from the parents/legal guardians (if under 18) and the participant is compulsory.
Exclusion criteria are:
Acute suicidality within the last 6 months
Life threatening self-harming behavior within the last 6 months
Substance-related or organic mental disorder
Pervasive developmental disorder
Acute or lifetime diagnosis of a psychotic disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV-TR )
Acute or lifetime diagnosis of a bipolar disorder according to DSM-IV-TR
Current diagnosis of substance dependence according to DSM-IV-TR (abstinence <6 months)
Mental retardation (IQ ≤75)
Simultaneous psychological or psychiatric treatment
Patients are enrolled either to TAU or D-CPT. Patients in TAU will be advised to look for treatment with other therapists in the respective areas. A detailed instruction to find a psychotherapist via internet will be given to the client by the coordinator of the respective study center. TAU patients will be monitored at the corresponding measurement points planned for D-CPT. After follow-up 1, patients can be enrolled into D-CPT if they wish to do so.
Overview of D-CPT
Therapy contract, emergency plan
Monitoring and identifying dysfunctional behavior and its long-term consequences
Using distress tolerance skills
Education about emotions
PTSD symptoms and psychological processes
Identifying maladaptive beliefs (“stuck points”)
Remembering the traumatic event through written accounts
Challenging stuck points
Focusing on special themes including safety, trust, control, esteem, and intimacy
Education about potentially abusive partners
Inclusion of social network
Severity of PTSD is measured at each assessment point using the CAPS-CA  (in German ). The CAPS-CA is a structured clinical interview which rates frequency and intensity of PTSD symptoms on a scale ranging from 0 (never) to 4 (daily or almost daily) and from 0 (none) to 4 (extreme), respectively. According to the German interview guidelines , a symptom is recorded as present if both frequency and intensity are at least rated with 1.
At pre- and post-treatment as well as at follow-up 1 and 2 assessments, psychiatric comorbidity is measured with the Structured Clinical Interview for DSM Disorders (SCID [38, 39], in German ), further important parts of the Diagnostic Interview for Mental Disorders in Childhood and Adolescence (Kinder-DIPS ), and the nicotine section of the Expert System for Diagnosing Mental Disorders (DIA-X ).
Moreover, patients are asked to complete a wide range of questionnaires measuring comorbidity and related problems at every assessment before and after treatment. Among these are:
Borderline Symptom List 23 (BSL-23 )
Besides, saliva samples are collected for high-throughput epigenetic profiling and psychophysiological parameters are assessed by EEG – each at baseline and follow-up 1.
Participants are tested with the Culture-Fair Intelligence Test (CFT-20-R ), which ensures that patients meet the cognitive requirements for treatment.
Detailed information about abuse are obtained by the Childhood Trauma Questionnaire (CTQ , in German ) and the Interview for Traumatic Events in Childhood (ITEC ). The ITEC is a retrospective, semi-structured interview for childhood maltreatment that provides dimensional scores for the severity of sexual, physical, and emotional abuse as well as emotional and physical neglect.
For the examination of mediators and moderators, like therapeutic alliance, maladaptive beliefs, and mental images, the Helping Alliance Questionnaire  (in German ), the Post-traumatic Maladaptive Beliefs Scale for Youth (PMBSY; Matulis S, Resick PA, Steil R, personal communication, 2012), and an instrument for the measurement of mental images (FVB; Schreiber F, Gutermann J, Matulis S, Steil R, personal communication, 2012) are used. Emotion regulation is assessed using the Affective Style Questionnaire (ASQ , in German ) and attachment is studied by the Experiences in Close Relationships – Revised Questionnaire (ECR-R , in German ). Therapeutic adherence and competence are rated on the basis of randomly drawn videographies of treatment sessions by independent raters using two newly developed rating scales, the D-CPT Adherence Scale  and the Cognitive Therapy Competence Scale for D-CPT .
Sample size calculation
A type I error of 0.05 and a statistical power of 0.8 were used for sample size calculations. As there exists no effect size estimation for TAU in Germany, we suggest an effect size of d = 0.3. Based on the data reported by Harvey and Taylor , an effect size of d = 0.9 was assumed for D-CPT. Thus, two groups of n = 45 patients are required for the trial. No adjustment for drop-out is necessary as last observation carried forward substitution of the major study endpoint will be performed during the intention-to-treat analysis.
To test the hypothesis that D-CPT is superior to TAU, a confirmatory analysis of the study will be calculated as a t-test of post-treatment scores of the CAPS-CA. The critical value of alpha will be set to 0.05. Additional analyses focusing on secondary study endpoints or on generating hypotheses for subsequent studies will be performed on an exploratory basis using up-to-date sophisticated statistical models.
Safety and ethical issues
The trial has been approved by the Ethics Committee of Catholic University Eichstätt-Ingolstadt and is conducted according to the ICH Guideline for Good Clinical Practice (ICH-GCP ). Prior to assessments, all patients are informed about study design and procedures including randomization, probable side effects, and the possibility of ending the participation at any time without disadvantages. Informed consent has to be provided by participating patients and by their parents or guardian if the adolescent is younger than 18 years of age. For safety reasons, suicidal tendencies are constantly observed during assessment and treatment. If necessary, patients will be referred to cooperating clinics. Serious adverse events (SAEs) are continuously monitored and reported through the whole trial. In correspondence with the ICH-GCP, the following incidents are defined as SAEs:
A physical disease with the risk of permanent impairment and a following medical intervention
Inpatient somatic hospitalization with a minimum of one overnight stay or prolongation of existing hospitalization
Inpatient psychiatric hospitalization with a minimum of one overnight stay or prolongation of existing hospitalization (including emergency accommodation/crisis intervention service)
Intoxication with psychotropic substances (including alcohol) and following medical intervention
Delinquency with judiciary or police contact
External aggression to property (statutory offense)
External aggression to persons (statutory offense)
Intentional self-harming behavior requiring medical aid
Re-victimization including all traumatic events according to DSM-IV-TR
In case of a SAE, the responsible therapist or study coordinator reports the event to his/her supervisor and an independent Data and Safety Monitoring Board (DSMB). The decision, whether there is a causal link between treatment and occurrence of SAEs, is taken by the DSMB. If severe safety concerns become apparent to the DSMB, the trial will be stopped.
If an investigator has ethical concerns because of the performance at one of the centers, the coordinating investigator or the co-principal investigator will be informed immediately. The coordinating investigator and the co-principal investigator are authorized to discontinue interventions in a trial center because of insufficient and/or inadequate recruitment, insufficient quality of data, or specific problems unforeseeable in advance which render the continuation of the study impossible at that specific center.
Although the severe psychopathological consequences of sexual and/or physical abuse are known, only few studies report on the results of trauma focused psychotherapy for adolescents [19–23]. Consequently, chances were hitherto missed to administer effective treatments in early life to prevent the development of severe comorbidity or re-victimization. Reasons for the lack of studies are manifold, and might be due to difficulties in psychological assessments differing for adolescents and young adults, as well as to legal issues around different licensing procedures for therapists treating children and adolescents and those treating adult patients. Moreover, the lack of studies might be related to the characteristics of adolescents, whose motivational instability, rapid and intensive mood changes, and disentanglement from family structures have the potential to impede treatment participation and completion. The only published study on a similar methodological level needed 6 years of randomization to finally include 61 adolescent girls . This highlights once more the specific problems in this age group. To bridge this knowledge gap by introducing a developmentally adapted CPT is the goal of the D-CPT network. The novelty of D-CPT is the adaption of the CPT procedure to the group of traumatized adolescents by increasing treatment intensity, integrating emotion-regulation-training, and finally by considering developmental tasks. The overall aim of the project is to evaluate this new therapy. Besides, the network aims to address several other heavily underexplored issues like variables influencing treatment outcome, epigenetics, health economics, and neurophysiological processing.
Taken together, the innovative character of our project is represented in i) a study sample of adolescents and young adults suffering from PTSD, ii) the developmentally adapted version of CPT (D-CPT) whose feasibility for youth within the German health system will be evaluated, and iii) measurement of the so far unknown effectiveness of TAU in Germany, which will be estimated.
Moreover, issues addressed in the D-CPT partner projects have a pioneering value. Predictors of treatment success like treatment adherence, therapist competence, and working alliance are not as well studied in PTSD as in other disorder specific interventions . The same applies to epigenetics and PTSD; to our knowledge, the D-CPT study will be the first clinical study analyzing epigenetic profiles of PTSD patients during the course of therapy  and it will be the first survey screening for epigenetic markers for PTSD in adolescents and young adults. Likewise, research on health economic evidence is rare for PSTD. Last but not least, the novelty in the examination of neurophysiological processing of threat cues in PTSD lies in the differentiation between maltreated subjects with and without psychopathology.
In summary, the D-CPT project will provide insight in a wide range of different issues concerning PTSD and its treatment in adolescents and young adults. We are confident that, in the long term, it will contribute to the improvement of psychotherapeutic care for this therapeutically underserved population.
The project is part of a comprehensive network about behavioral disorders related to violence, neglect, maltreatment, and abuse in childhood and adolescence.
The trial started in October 2012 and will end in 2015/2016. Patient enrolment is ongoing with 31 of the 90 participants having been recruited.
Beck Depression Inventory
Affective Style Questionnaire
Clinician Administered PTSD Scale for Children and Adolescents
Childhood physical abuse
Cognitive Processing Therapy
Childhood sexual abuse
Client Sociodemographic and Service Receipt Inventory
Dialectical Behavior Therapy
Developmentally Adapted Cognitive Processing Therapy
Expert System for Diagnosing Mental Disorders
Data and Safety Monitoring Board
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition
Experiences in Close Relationships – Revised
EuroQol 5 Dimensions
Fragebogen zur Erfassung mentaler Vorstellungsbilder
ICH Guideline for Good Clinical Practice
Diagnostic Interview for Assessment of Psychological Disorders in Childhood and Adolescence
Post-traumatic Maladaptive Beliefs Scale for Youth
Post-traumatic stress disorder
Randomized controlled trial
Serious adverse event
Structured Clinical Interview for DSM Disorders
Treatment as usual
University of California Los Angeles PTSD Reaction Index
The study is funded by the German Federal Ministry of Education and Research (BMBF; 01KR1204A). The authors thank Babette Renneberg from Freie Universität Berlin for the supervision of one of the three university outpatient clinics and the support to bring the study to a successful end. We thank Eline Rimane for transferring the proposal and trial registration into the first draft of the manuscript.
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