Table 3 Methodological characteristics of included studies
From: Funding source and the quality of reports of chronic wounds trials: 2004 to 2011
All (n = 167) | Leg ulcers (n = 63) | Pressure ulcers (n = 31) | Foot ulcers (n = 57) | |
|---|---|---|---|---|
Number of participants(median (IQ range)) | ||||
Overall | 60 (35 to 99) | 81 (43 to 126) | 44 (26 to 60) | 50 (30 to 86) |
Per treatment arm | 28 (16 to 47) | 37 (21 to 62) | 21 (7 to 30) | 27 (15 to 43) |
Duration(in months; median (IQ range)) | ||||
All | 2.8 (1.6 to 5.6) | 3.0 (2.8 to 6.0) | 1.9 (0.9 to 3.3) | 3.0 (1.4 to 4.7) |
PO: Complete healing | 5.6 (3.0 to 6.1) | 6 (3.0 to 12) | 3.9 (1.3 to 6) | 4.7 (4.7 to 5.6) |
PO: Surrogate healing | 2.8 (1.7 to 3.7) | 2.8 (1.9 to 3.0) | 1.6 (0.93 to 2.8) | 1.9 (1.1 to 3.4) |
PO: Nonhealing | 1.7 (1.4 to 2.1) | 1.9 (1.6 to 36) | 1.4 (1.4 to 1.4) | 1.9 (1.4 to 3.9) |
PO: Not defined | 2.8 (1.3 to 4.3) | 3 (1.6 to 5.6) | 1.8 (0.85 to 3.0) | 2.8 (0.93 to 3.7) |
Primary outcome | ||||
Complete Healing | 40 (24%) | 18 (29%) | 4 (13%) | 16 (28%) |
Surrogate Healing | 47 (28%) | 15 (24%) | 14 (45%) | 12 (21%) |
Non-healing | 11 (6.6%) | 3 (4.8%) | 1 (3.2%) | 6 (11%) |
None | 69 (41%) | 27 (43%) | 12 (39%) | 23 (40%) |
Sequence generation | ||||
Low RoB | 67 (40%) | 27 (43%) | 15 (48%) | 19 (33%) |
Unclear RoB | 98 (59%) | 36 (57% | 15 (48%) | 37 (65%) |
High RoB | 2 (1.2%) | 0 (0.0)% | 1 (3.2%) | 1 (1.6%) |
Allocation concealment | ||||
Low RoB | 41 (25%) | 22 (35%) | 5 (16%) | 11 (19%) |
Unclear RoB | 123 (74%) | 41 (65%) | 24 (77%) | 45 (80%) |
High RoB | 3 (1.8%) | 0 (0.0%) | 2 (6.5%) | 1 (1.6%) |
Blinding of assessors | ||||
Low RoB | 56 (34%) | 13 (21%) | 15 (48%) | 23 (40%) |
Unclear RoB | 64 (38%) | 24 (38%) | 13 (42%) | 22 (39%) |
High RoB | 47 (28%) | 26 (41%) | 3 (9.7%) | 12 (21%) |
Overall RoB | ||||
Low RoB | 10 (6.0%) | 4 (6.3%) | 2 (6.5%) | 3 (5.3%) |
Unclear RoB | 107 (64%) | 33 (52%) | 24 (77%) | 41 (72%) |
High RoB | 50 (30%) | 26 (41%) | 5 (16%) | 13 (23%) |