Study | Disease area | Study type | Sample size | Outcome measure | Outcome type | Prognostic covariates |
---|---|---|---|---|---|---|
AUGIB | Acute upper gastrointestinal bleeding | Observational study | 600a | Mortality in hospital | Binary | (1) clinical Rockall score |
Further bleeding in hospital | Binary | (1) clinical Rockall score | ||||
RBC transfusion in hospital | Binary | (1) presence of shock; (2) haemoglobin concentration at baseline | ||||
FASTER | Postoperative rehabilitation | RCT | 316 | Oswestry disability index | Continuous | (1) Oswestry disability index at baseline; (2) type of surgery |
MIST2 | Malignant pleural effusion | RCT | 210 | Size of the patient’s pleural effusion at 7 days | Continuous | (1) size of the pleural effusion at baseline; (2) hospital-acquired infection; (3) large tube size; (4) drain present |
Need for surgery at 90Â days | Binary | (1) size of the pleural effusion at baseline; (2) large tube size | ||||
MOSAIC | Sleep apnoea | RCT | 391 | Epworth Sleepiness Score | Continuous | (1) Epworth Sleepiness Score at baseline; (2) sex; (3) MRI received at baseline |
PBC | Primary biliary cirrhosis | RCT | 312 | Time to death | Time-to-event | (1) age; (2) albumin concentration; (3) bilirubin concentration; (4) histological stage |
PROGRAMS | Extremely preterm, small for gestational age neonates | RCT | 280 | Sepsis-free survival up to day 14 | Binary | (1) gestational age at birth; (2) birth weight |
Mortality up to day 14 | Binary | (1) gestational age at birth; (2) birth weight | ||||
RE01 | Metastatic renal carcinoma | RCT | 347 | Time to death | Time-to-event | (1) WHO score; (2) tumour grade; (3) white cell count |
TIME2 | Malignant pleural effusion | RCT | 106 | Mean breathlessness over 42Â days | Continuous | (1) breathlessness at baseline; (2) performance status; (3) mesothelioma |