Table 1 Summary of moxifloxacin-TB studies
In vitro | Year | Key | Outcome | Children |
|---|---|---|---|---|
Ji et al. [15] | 1998 | u 1 | Positive | v 1 |
Gillespie et al. [16] | 1999 | u 2 | Positive | w 1,w 2 |
Shandil et al. [17] | 2007 | u 3 | Positive | w 5,w 6 |
In vivo | Â | Â | Â | Â |
Ji et al. [15] | 1998 | v 1 | Positive | v 2 |
Miyazaki et al. [18] | 1999 | v 2 | Positive | v 3,w 1 |
Lounis et al. [19] | 2001 | v 3 | Positive | v 4 |
Yoshimatsu et al. [20] | 2002 | v 4 | Inconclusive | v 5 |
Nuermberger et al. [21] | 2004 | v 5 | Inconclusive | u 3,w 3,w 4 |
Phase 1 | Â | Â | Â | Â |
Gosling et al. [22] | 2003 | w 1 | Positive | v 5 |
Pletz et al. [23] | 2004 | w 2 | Positive | v 5 |
Gillespie et al. [24] | 2005 | w 3 | Negative | x 1 |
Johnson et al. [25] | 2006 | w 4 | Positive | x 1,x 2 |
Nijland et al. [26] | 2007 | w 5 | Negative | – |
Peloquin et al. [27] | 2008 | w 6 | Inconclusive | x 4 |
Phase 2 | Â | Â | Â | Â |
Burman et al. [28] | 2006 | x 1 | Negative | w 5,w 6,x 3,x 4 |
Rustomjee et al. [29] | 2007 | x 2 | Positive | x 3 |
Conde et al. [30] | 2009 | x 3 | Positive | x 5 |
Dorman et al. [31] | 2009 | x 4 | Negative | – |
Wang et al. [32] | 2009 | x 5 | Positive | – |