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Table 8 Parameters of the four-stage trial design used in the simulation study. See text for details

From: Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

Stage(i)

α i

ω i

δ i

e i

1

0.5

0.95

1.000

73

2

0.25

0.95

0.923

140

3

0.1

0.95

0.884

217

4

0.025

0.9

0.843

262

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Trials

ISSN: 1745-6215