Table 1 Simulated data from a randomised trial comparing two groups of 30, with no real difference.
From: Comparisons against baseline within randomised groups are often used and can be highly misleading
Group A | Group B | ||||||
|---|---|---|---|---|---|---|---|
Baseline | Final | Baseline | Final | Baseline | Final | Baseline | Final |
2.6 | 2.7 | 9.7 | 11.7 | 6.0 | 5.9 | 11.0 | 11.2 |
5.5 | 5.0 | 9.8 | 9.6 | 7.3 | 6.8 | 11.1 | 12.3 |
6.5 | 6.1 | 10.3 | 10.3 | 7.6 | 6.2 | 11.2 | 11.1 |
7.5 | 8.7 | 10.6 | 10.4 | 7.6 | 7.8 | 11.2 | 12.0 |
7.9 | 9.3 | 11.0 | 11.0 | 8.2 | 7.8 | 11.4 | 11.2 |
8.0 | 9.4 | 11.2 | 10.8 | 8.7 | 9.5 | 11.5 | 10.9 |
8.2 | 9.1 | 11.3 | 11.5 | 8.9 | 9.9 | 11.8 | 11.2 |
8.3 | 7.9 | 11.5 | 11.6 | 9.0 | 10.6 | 11.8 | 13.8 |
8.4 | 8.1 | 11.6 | 11.8 | 9.0 | 11.7 | 11.9 | 12.6 |
8.6 | 9.2 | 12.0 | 12.1 | 9.4 | 9.8 | 11.9 | 13.2 |
8.7 | 9.7 | 12.4 | 13.4 | 9.8 | 9.9 | 12.3 | 10.3 |
8.7 | 10.4 | 12.4 | 15.8 | 10.5 | 10.2 | 12.5 | 11.3 |
9.0 | 7.4 | 12.5 | 13.8 | 10.5 | 11.2 | 12.8 | 13.1 |
9.2 | 9.7 | 12.7 | 12.5 | 10.9 | 11.5 | 13.0 | 14.4 |
9.4 | 9.4 | 14.9 | 16.5 | 10.9 | 12.5 | 13.2 | 13.3 |