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Figure 2 | Trials

Figure 2

From: Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

Figure 2

Power curves for 2 × 2 factorial designs with an interaction assuming equal individual contributions from both treatments corresponding to hazard ratios of 0.84 and an overall mortality of 35%. Figure legend text: The blue lines correspond to the power of the interaction test (solid line: one-sided 2.5% significance level, dashed line: one-sided 10% significance level), the black line to the power of the main effect for treatment A, and the green line to the power of a 2-group trial of combination treatment versus standard treatment with equal sample size.

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Trials

ISSN: 1745-6215