Pre-referral rectal artesunate in severe malaria: flawed trial

Table 3 ITT analyses under three scenarios

Status	Scenario I		Scenario II		Scenario III
	Artesunate	Placebo	Artesunate	Placebo	Artesunate	Placebo
Dead*	258	288	258	296	258	288
Alive*& PD	15	22	15	22	15	30
Alive*& No PD	8681	8562	8681	8554	8681	8554
Total	8954	8872	8954	8872	8954	8872
p-value**	0.18		0.11		0.027

Note: These analyses include all the cases as randomized and use the data Figure one of Gomes et al. Scenario I assumes that the eight missing cases were alive and without PD, scenario II assumes they were dead, and scenario III assumes they were alive but with PD; *Dead or Alive by day of 7-30 day follow up; **Chi-square p-value.

ISSN: 1745-6215