Table 3 Clinical outcomes according to randomized allocation of clonidine treatment (ITT).
Placebo | Level 1 | Level 2 | Level 3 | P value | |
|---|---|---|---|---|---|
n = 12 | n = 12 | n = 12 | n = 12† | ||
GCS < 15 | |||||
Pre Intervention | 7(58%) [30 to 83] | 4(33%) [12 to 62] | 7(58%) [30 to 83] | 5(41%) [17 to 70] | 0.52 |
Post Intervention | 5(42%) [17 to 70] | 3(25%) [7 to 54] | 5(42%) [17 to 70] | 6(50%) [23 to 77] | 0.64 |
GCS ≤ 8 | |||||
Pre Intervention | 2(17%) [3 to 45] | 0(0%) [0 to 22] | 1(8%) [0.4 to 35] | 1(8%) [0.4 to 35] | 0.53 |
Post Intervention | 1(8%) [0.4 to 35] | 1(8%) [0.4 to 35] | 1(8%) [0.4 to 35] | 2(17%) [3 to 45] | 0.88 |
Hypotension* | 0(0%) [0 to 22] | 0(0%) [0 to 22] | 0(0%) [0 to 22] | 6(50%) [23 to 77] | <0.001 £ |
Ventilation | 4(33%) [12 to 62] | 3(25%) [7 to 54] | 0(0%) [0 to 22] | 4(33%) [12 to 62] | 0.17 |
Death | 1(8%) [0.4 to 35] | 0(0%) [0 to 22] | 0(0%) [0 to 22] | 3(25%) [7 to 54] | 0.08 |
Ventilated or death | 4(33%) [12 to 62] | 3(25%) [7 to 54] | 0(0%) [0 to 22] | 4(33%) [12 to 62] | 0.17 |