A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning

Table 2 Atropine Doses in RCT pre and post commencement of the clonidine infusion.

	Placebo	Level 1	Level 2	Level 3	P value
	n = 12	n = 12	n = 12	n = 12†
Pre clonidine dosing
Atropine Bolus (mg)	9 (2–28)	6 (1–12)	2 (1–6)	6 (3–24)	0.19
Atropine Infusion (mg/hour)	10 (1–24)	1 (1–1)	1 (1-1)	5 (1–11)	0.008 ^£
Post clonidine dosing
Atropine Bolus (mg)	6 (2–9)	1 (0–1)	0(0–3)	1 (1–15)	0.05
Atropine Infusion (mg/hour)	2 (0–16)	1 (1-1)	1 (0–2)	6 (1–15)	0.47

Data are Median (IQR); †One patient died after randomization before receiving clonidine. Comparisons between the three groups were made using a Kruskal-Wallis.^£P < 0.05 by Kruskal-Wallis with post hoc Dunn's test between level 2 and level 3 groups.

ISSN: 1745-6215